Chemical structure:
IUPAC name:
2-[(4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid
CAS number:
808118-40-3
Therapy area:
anti-anemia
References:
IH
Status:
Under development
Mechanism of action
Roxadustat (FG-4592) is a prolyl hydroxylase inhibitor of hypoxia-inducible factor (PHI). Prolyl hydroxylase domain protein (PHD) activity is inhibited as the principal mode of action when normoxia is present. Three subtypes of hypoxia-inducible factor (HIF-) exist: 1, 2, and 3. HIF- has just one subtype.
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