Clopidogrel Bisulphate

Chemical structure:

 

IUPAC name:

(+)-(S)-methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate

 

CAS number:

113665-84-2

 

Therapy area:

Anti-coagulant

 

References:

IP/USP/Ph.Eur

 

Status:

Commercial sale

 

Mechanism of action

Clopidogrel is activated by the enzymes CYP2C19, CYP1A2, and CYP2B6 in two phases, followed by CYP2C19, CYP2C9, CYP2B6, and CYP3A. The P2Y12 subtype of the ADP receptor, which is crucial for the activation of platelets and eventual cross-linking by the protein fibrin, is thus selectively and irreversibly inhibited by the active metabolite. When a quick effect is required, a loading dosage of either 600 or 300 mg of oral clopidogrel is delivered since platelet inhibition can be seen two hours after a single dose, but the drug’s beginning of action is sluggish.