Chemical structure:

IUPAC name:

(RS)-N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine

CAS number:

60-87-7, 58-33-3 (HCl)

Therapy area:

Anti-Histamine

References:

IH/EP/USP

Status:

Under development

Mechanism of action

The histamine H1 receptor, post-synaptic mesolimbic dopamine, alpha adrenergic, muscarinic, and NMDA receptors are all antagonists of promethazine. To treat allergic responses, antihistamines are utilised. , and  Promethazine can be used to treat nausea and vomiting because it inhibits histamine H1, muscarinic, and dopamine receptors in the medullary vomiting centre.

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