Chemical structure:

IUPAC name:

2-[(4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid

CAS number:

808118-40-3

Therapy area:

anti-anemia

References:

IH

Status:

Under development

Mechanism of action

Roxadustat (FG-4592) is a prolyl hydroxylase inhibitor of hypoxia-inducible factor (PHI). Prolyl hydroxylase domain protein (PHD) activity is inhibited as the principal mode of action when normoxia is present. Three subtypes of hypoxia-inducible factor (HIF-) exist: 1, 2, and 3. HIF- has just one subtype.

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